Definition

1. Noun:
   • A genetic disorder affecting connective tissue: Marfan's syndrome is an inherited condition that impacts the body's connective tissue, which provides strength and elasticity to structures throughout the body.
   • A disorder characterized by specific physical traits: It is notably characterized by unusual elongation of the bones, particularly in the limbs, fingers, and toes, and by potential complications in the eyes and cardiovascular system.

Usage Examples

• Noun:
  • The diagnosis of Marfan's syndrome explained the patient's unusually long limbs and spinal curvature.
  • Regular cardiac screenings are crucial for individuals with Marfan's syndrome due to the risk of aortic complications.

Advanced Usage

• "to have/manage/live with Marfan's syndrome": Common verb collocations describing the relationship with the condition.
  • Advances in medicine help many people manage Marfan's syndrome effectively.
• Used in medical, genetic, and patient-advocacy contexts to discuss diagnosis, treatment, and lifestyle adaptations.

Variants and Related Words

• Marfan syndrome: A common variant spelling that omits the possessive 's'. Both "Marfan's syndrome" and "Marfan syndrome" are accepted terms in medical literature.
• Connective tissue disorder: The broader category of conditions to which Marfan's syndrome belongs.

Synonyms

• Fibrillinopathy (type 1): A more technical synonym referencing the specific protein (fibrillin-1) affected by the genetic mutation.
• MFS: A common initialism for Marfan Syndrome.

Notes on Meaning

This term refers specifically to a single, defined medical condition. It does not describe general symptoms but is the name of the syndrome itself. The primary meaning is always the genetic disorder.

Noun

1. an autosomal dominant disease characterized by elongated bones (especially of limbs and digits) and abnormalities of the eyes and circulatory system